RCMP were warning about highway conditions west of Calgary on Friday night.
Mounties say about 15 vehicles were involved in a collision on the Trans-Canada Highway.
It happened in the westbound lanes at the Lac des Arcs overpass around 7:30 p.m.
Police say driving conditions were very poor in the area, with limited visibility.
As of 9 p.m., only minor injuries had been reported.
The road was down to one lane westbound while emergency crews helped the injured and cleared the wreckage.